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Ratain, Mark J.
One or more keywords matched the following items that are connected to Ratain, Mark J.
Item TypeName
Concept Administration, Inhalation
Concept Administration, Oral
Concept United States Food and Drug Administration
Concept Drug Administration Schedule
Academic Article 5-Fluorouracil, hydroxyurea and escalating doses of iododeoxyuridine with concomitant radiotherapy for malignant gliomas: a clinical and pharmacologic analysis.
Academic Article A phase I study of subcutaneous recombinant interleukin-2 and interferon alfa-2a.
Academic Article Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis.
Academic Article Dose-escalation trial of cladribine using five daily intravenous infusions in patients with advanced hematologic malignancies.
Academic Article Mineralocorticoid insufficiency due to suramin therapy.
Academic Article Pharmacodynamic modeling of prolonged administration of etoposide.
Academic Article Individualized dosing of amonafide based on a pharmacodynamic model incorporating acetylator phenotype and gender.
Academic Article New phase I trial methodology.
Academic Article Suramin: is adaptive control necessary?
Academic Article Learning from our patients: one participant's impact on clinical trial research and informed consent.
Academic Article Study of cohort-specific consent and patient control in phase I cancer trials.
Academic Article Phase I study of 3'-deamino-3'-(2-methoxy-4-morpholinyl)doxorubicin (FCE 23762, PNU 152243) administered on a daily x3 schedule.
Academic Article Phase I study of treatment with oral 13-cis-retinoic acid, subcutaneous interferon alfa-2a, cisplatin, and 24-hour infusion 5-fluorouracil/leucovorin.
Academic Article Pharmacokinetics and pharmacodynamics of oltipraz as a chemopreventive agent.
Academic Article Oral chemotherapy: rationale and future directions.
Academic Article Pharmacokinetics and pharmacodynamics of 9-aminocamptothecin infused over 72 hours in phase II studies.
Academic Article Phase I study of ZD9331 on short daily intravenous bolus infusion for 5 days every 3 weeks with fixed dosing recommendations.
Academic Article Phase I Trial of ISIS 5132, an antisense oligonucleotide inhibitor of c-raf-1, administered by 24-hour weekly infusion to patients with advanced cancer.
Academic Article Rationale for phase I study of UFT plus leucovorin and oral JM-216.
Academic Article Body-surface area as a basis for dosing of anticancer agents: science, myth, or habit?
Academic Article Pharmacology of 21-day oral etoposide given in combination with i.v. cisplatin in patients with extensive-stage small cell lung cancer: a cancer and leukemia group B study (CALGB 9062).
Academic Article A phase I study of oral uracil/ftorafur (UFT) plus leucovorin and bis-acetato-ammine-dichloro-cyclohexylamine-platinum IV (JM-216) each given over 14 days every 28 days.
Academic Article A Phase I study of raltitrexed and paclitaxel given every 3 weeks to patients with solid tumors.
Academic Article 5-fluorouracil pharmacokinetics: causes for variability and strategies for modulation in cancer chemotherapy.
Academic Article 5-Fluorouracil, leucovorin, hydroxyurea, and escalating doses of continuous-infusion cisplatin with concomitant radiotherapy: a clinical and pharmacologic study.
Academic Article Development of a schedule-dependent population pharmacodynamic model for rhizoxin without quantitation of plasma concentrations.
Academic Article Dose-escalating study of capecitabine plus gemcitabine combination therapy in patients with advanced cancer.
Academic Article Phase I study to evaluate multiple regimens of intravenous 5-fluorouracil administered in combination with weekly gemcitabine in patients with advanced solid tumors: a potential broadly active regimen for advanced solid tumor malignancies.
Academic Article Relationship of baseline serum bilirubin to efficacy and toxicity of single-agent irinotecan in patients with metastatic colorectal cancer.
Academic Article Dose-ranging study of the safety and pharmacokinetics of atrasentan in patients with refractory malignancies.
Academic Article Randomized discontinuation design: application to cytostatic antineoplastic agents.
Academic Article A phase I trial of escalating doses of trastuzumab combined with daily subcutaneous interleukin 2: report of cancer and leukemia group B 9661.
Academic Article A phase I trial of gemcitabine plus cladribine in patients with advanced hematologic malignant diseases.
Academic Article A phase I study of the oral combination of CI-994, a putative histone deacetylase inhibitor, and capecitabine.
Academic Article Weekly, high-dose paclitaxel in advanced lung carcinoma: a phase II study with pharmacokinetics by the Cancer and Leukemia Group B.
Academic Article Pharmacokinetics, pharmacodynamics and adherence to oral topotecan in myelodysplastic syndromes: a Cancer and Leukemia Group B study.
Academic Article Prescribing oral chemotherapy.
Academic Article Phase II placebo-controlled randomized discontinuation trial of sorafenib in patients with metastatic renal cell carcinoma.
Academic Article Phase I study of inhaled Doxorubicin for patients with metastatic tumors to the lungs.
Academic Article The value meal: how to save $1,700 per month or more on lapatinib.
Academic Article Clinical pharmacokinetics of high-dose leucovorin calcium after intravenous and oral administration.
Academic Article A Phase II trial of suramin monthly x 3 for hormone-refractory prostate carcinoma.
Academic Article Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor.
Academic Article Phase I and pharmacokinetic study of sorafenib in patients with hepatic or renal dysfunction: CALGB 60301.
Academic Article R(+)XK469 inhibits hydroxylation of S-warfarin by CYP2C9.
Academic Article Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation.
Academic Article Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer.
Academic Article Phase I and pharmacokinetic study of erlotinib for solid tumors in patients with hepatic or renal dysfunction: CALGB 60101.
Academic Article Flushing oral oncology drugs down the toilet.
Academic Article Adaptive control of etoposide administration: impact of interpatient pharmacodynamic variability.
Academic Article Why RECIST works and why it should stay--reply to counterpoint.
Academic Article Activity of XL184 (Cabozantinib), an oral tyrosine kinase inhibitor, in patients with medullary thyroid cancer.
Academic Article Nonprofit biomedical companies.
Academic Article Interferon treatment for hairy cell leukemia. An update on a cohort of 69 patients treated from 1983 to 1986.
Academic Article Phase I trial of granulocyte-macrophage colony-stimulating factor plus high-dose cyclophosphamide given every 2 weeks: a Cancer and Leukemia Group B study.
Academic Article A randomized study of inpatient versus outpatient continuous infusion chemotherapy for patients with locally advanced head and neck cancer.
Academic Article Relapse after interferon alfa-2b therapy for hairy-cell leukemia: analysis of prognostic variables.
Academic Article The UGT1A1*28 polymorphism correlates with erlotinib's effect on SN-38 glucuronidation.
Academic Article Inconsistent labeling of food effect for oral agents across therapeutic areas: differences between oncology and non-oncology products.
Academic Article Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer.
Academic Article Importance of food effects for oral oncology drugs.
Academic Article Sequential therapy with dacarbazine and carmustine: a phase I study.
Academic Article Phase I trial of a genetically engineered interleukin-2 fusion toxin (DAB486IL-2) as a 6 hour intravenous infusion in patients with hematologic malignancies.
Academic Article Phase I study of suramin given by intermittent infusion without adaptive control in patients with advanced cancer.
Academic Article A phase I study of intermittent infusion cladribine in patients with solid tumors.
Academic Article Phase I and pharmacokinetic study of a new antineoplastic agent: pyrazine diazohydroxide (NSC 361456).
Academic Article A phase I and pharmacokinetic study of the quinoxaline antitumour Agent R(+)XK469 in patients with advanced solid tumours.
Academic Article Five-day infusional fluorodeoxyuridine with oral leucovorin and escalating doses of interferon alpha-2b: a phase I study.
Academic Article Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics.
Academic Article Dose-escalation models for combination phase I trials in oncology.
Academic Article Low-dose interferon alfa-2b in the treatment of hairy cell leukemia.
Academic Article Human plasma pharmacokinetics of thiotepa following administration of high-dose thiotepa and cyclophosphamide.
Academic Article Amonafide: An active agent in the treatment of previously untreated advanced breast cancer--a cancer and leukemia group B study (CALGB 8642).
Academic Article Body surface area as a determinant of pharmacokinetics and drug dosing.
Academic Article Phase 1 dose escalation study of docetaxel with filgrastim support in patients with advanced solid tumors.
Academic Article Phase I study of an oral formulation of ZD9331 administered daily for 28 days.
Academic Article Dose-ranging pharmacodynamic study of tipifarnib (R115777) in patients with relapsed and refractory hematologic malignancies.
Academic Article Phase I study of adozelesin administered by 24-hour continuous intravenous infusion.
Academic Article Plasma pharmacokinetics of high-dose oral melphalan in patients treated with trialkylator chemotherapy and autologous bone marrow reinfusion.
Academic Article Opportunities and challenges in the development of experimental drug combinations for cancer.
Academic Article Preventing adverse drug-drug interactions: a need for improved data and logistics.
Academic Article Are drug labels static or dynamic?
Academic Article Conventional dosing of anticancer agents: precisely wrong or just inaccurate?
Academic Article First-in-human phase I study of Lurbinectedin (PM01183) in patients with advanced solid tumors.
Academic Article Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion.
Academic Article Drug-Drug Interactions With Oral Antineoplastic Agents.
Academic Article Phase I study of lurbinectedin, a synthetic tetrahydroisoquinoline that inhibits activated transcription, induces DNA single- and double-strand breaks, on a weekly × 2 every-3-week schedule.
Academic Article An initial genetic analysis of gemcitabine-induced high-grade neutropenia in pancreatic cancer patients in CALGB 80303 (Alliance).
Academic Article A Cost-Focused Alternative Cancer Medication Dispensing Strategy-"Pack Splitting".
Academic Article Alternative dosing regimens for atezolizumab: right dose, wrong frequency.
Academic Article Personalized Management of Chemotherapy-Induced Peripheral Neuropathy Based on a Patient Reported Outcome: CALGB 40502 (Alliance).
Academic Article Weight-Based Dosing of Pembrolizumab Every 6 Weeks in the Time of COVID-19.
Academic Article Accelerated Approval of Anticancer Drugs: Lessons Learned From the Example of Olaratumab.
Academic Article The Right Dose: From Phase I to Clinical Practice.
Academic Article Dose Optimization of Sotorasib: Is the US Food and Drug Administration Sending a Message?
Concept Administration, Intravenous
Academic Article Interventional pharmacoeconomics for immune checkpoint inhibitors through alternative dosing strategies.
Academic Article Project Optimus: Is the US Food and Drug Administration Waiving Dose Optimization for Orphan Drugs?
Academic Article Special designations and the US Food and Drug Administration's "dual mandate".
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